A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility
نویسندگان
چکیده
منابع مشابه
P-24: Beta Defensin 126 and Its Role in Intra-Uterine Insemination Outcome
Background: Human β-defensin 126 is a small cationic glycoprotein that coats the plasma membrane of sperm during epididymal transit. It provides protection for sperms from infection-causing microbes and against the female immune system. Defensin remains on the sperm until sperm become capacitated in the female reproductive tract. DEFB126 gene is located on the subtelomeric end of 20p13 in human...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2011
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3002289